Tick-borne affliction, informally

Latest answer — September 11, 2025

33 Across

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NYT Crossword

This clue's Thursday, September 11, 2025 appearance

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Across

  1. 1City with a view of Mount Vesuvius
  2. 7Minuscule, in cutesy lingo
  3. 13"Seinfeld" role
  4. 14Came unglued
  5. 15Hand-held communication device
  6. 16Get cranky with fatigue, maybe
  7. 17Dangers in "The Hurt Locker," for short
  8. 18Longtime portrayer of TV's Captain Pierce
  9. 19Jam
  10. 21Check out
  11. 23Total
  12. 28Microdosing substance
  13. 29Blowout
  14. 30Sound in a horror film
  15. 31Simpson née Bouvier
  16. 33Tick-borne affliction, informally
  17. 35Treats, as a sprain
  18. 36Back-to-back sporting events ... with a hint to the answers to the italicized clues
  19. 39Marinara tomato
  20. 40Kind of surgeon
  21. 41HI hi
  22. 43Pair of words that are usually contracted
  23. 45Curved shapes
  24. 47Lush
  25. 48One laying a foundation
  26. 49Turner of rock
  27. 50Video surveillance letters
  28. 51"I Am ___," onetime reality TV spinoff
  29. 53"Out!"
  30. 55Region of South Dakota
  31. 59Nursery rhyme character known as Lille Trille in Denmark
  32. 62Author who created Heffalumps and Woozles
  33. 63Current measure
  34. 64Flashiness
  35. 65Answer with a salute

Down

  1. 1Semiaquatic amphibian
  2. 2Resembling
  3. 3Mom, dad and sis, but not bro
  4. 4Took a shine to
  5. 5City WNW of Tulsa
  6. 6Handles
  7. 7Material with a coarse weave
  8. 8Long hyphen
  9. 9H
  10. 10Grandma, in Gloucester
  11. 11Steamy place
  12. 12"You betcha"
  13. 14Lash mark
  14. 16Vices that are best abandoned
  15. 19Antiracist movement since 2013, for short
  16. 20Dance pioneer Duncan
  17. 22Leonhard who helped develop calculus
  18. 24Archangel in "Paradise Lost"
  19. 25Powerful ones have resolutions less than 0.1 nanometer
  20. 26Something one might slice
  21. 27Approves
  22. 29Graycoat in the Civil War
  23. 30Briny
  24. 32Organic fertilizer
  25. 34Casaba, e.g.
  26. 37Plethora
  27. 38Courtroom figs.
  28. 39Butter from a farm
  29. 42Dune buggy, e.g., in brief
  30. 44Ready for an emergency, say
  31. 46Time for a trip to the laundromat
  32. 49Alternative to Gain
  33. 50Guest freebies
  34. 52Youngest of the Brontë sisters
  35. 54Philosopher David who wrote "A Treatise of Human Nature"
  36. 55Medieval entertainer
  37. 56Good rating for a bond
  38. 57Noncombat region, in brief
  39. 58Cheney of politics
  40. 60Prefix with lingual or lateral
  41. 61"___ Blues" (song on the Beatles' "White Album")

The answer to “Tick-borne affliction, informally” in the New York Times crossword is LYME — a 4-letter word. It most recently appeared in the New York Times crossword on September 11, 2025, a Thursday puzzle, at 33-Across. Below you'll find why that fill fits, every other answer we've recorded for this clue, and links into the puzzle it came from.

“Tick-borne affliction, informally” answer

LYME (4 letters)

Reveal the solution one letter at a time with the tiles above if you'd rather nudge yourself toward it than see the whole word at once. Just want it outright? The answer is LYME.

Why the answer is LYME

LYME is the 4-letter solution that fits "Tick-borne affliction, informally" in the NYT Crossword crossword on September 11, 2025 (33-Across). Use the letter tiles above if you'd rather reveal it one letter at a time.

What does LYME mean?

Reading the plain dictionary sense of LYME is often the fastest way to see why it answers this clue.

(noun)

  • a form of arthritis caused by bacteria that are transmitted by ticks

When else has “Tick-borne affliction, informally” appeared?

New York Times reuses clues across dates, sometimes with a different answer depending on the grid. Here's where this exact clue has shown up, and what the answer was each time — handy when you're checking whether today's fill is the only one.

September 11, 2025 (most recent) → LYME. We haven't indexed another appearance of this exact clue yet.

Frequently asked questions

What is the answer to “Tick-borne affliction, informally”?

The answer is LYME, a 4-letter word. It most recently appeared in the New York Times crossword on September 11, 2025.

How many letters is the answer to “Tick-borne affliction, informally”?

4 letters: LYME.

When did this clue appear?

Most recently in the New York Times crossword on September 11, 2025 (a Thursday puzzle), at 33-Across.

Can “Tick-borne affliction, informally” have a different answer?

Yes — New York Times sometimes reuses a clue with a different solution to fit the grid. The answers we've recorded for each date it appeared are listed above when available.

Where can I find the rest of this day's NYT Crossword answers?

The full grid for September 11, 2025 is on the NYT Crossword answers page, with every clue and answer from that puzzle.

New York Times Crossword is published by The New York Times; WordHint is an independent site and is not affiliated with or endorsed by the publisher.

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