Toothache medication

Latest answer — November 22, 2025

46 Down

Scroll down for rest of crossword answers

NYT Crossword

This clue's Saturday, November 22, 2025 appearance

Tap a square to reveal a letter.

Or reveal one clue at a time with the Hint and Answer buttons below.

Across

  1. 1One of 843 in New York's 50-Across
  2. 5Sprinkle with oil, say
  3. 10Sister's commitments
  4. 14Foreign exchange?
  5. 16Essayist who wrote "If you wrest my words beyond their fair construction, it is you, and not I, that are the April Fool"
  6. 17End of a set, in mathematics
  7. 18Howard who wrote "A People's History of the United States"
  8. 19Eagle pose, for one
  9. 20Smooths
  10. 22Loll
  11. 23Boos
  12. 26Eponym of a renamed N.Y.C. bridge
  13. 29Number of Academy Award nominations for Best Actor received by Laurence Olivier
  14. 30Poked
  15. 32Stony
  16. 34Chris formerly of "S.N.L"
  17. 36Actress Kelly of Netflix's "3 Body Problem"
  18. 37Many Haitians
  19. 39Opening on a frozen lake
  20. 41Transit option since 2000
  21. 42Kind of butter used in lotions
  22. 44Many a sports bet
  23. 45Lead role in 1978's "La Cage aux Folles"
  24. 47With 10-Down, again, in Acapulco
  25. 49Miss the mark
  26. 50See 1-Across
  27. 53Counterpart of "Pls"
  28. 54Ruthless Records co-founder
  29. 55Get on
  30. 59Only player with two numbers retired by the L.A. Lakers
  31. 61Exhibit hoppi-ness?
  32. 63They cut bouts short, for short
  33. 64Disappearing ink vessel?
  34. 65Heat transfer?
  35. 66Red Square presence since 1924
  36. 67X or Y, often

Down

  1. 1Soft shade
  2. 2One of four tarot suits
  3. 3Half of "Live With Kelly and Mark"
  4. 4Delightful locales
  5. 5"Gimme a sec"
  6. 6Laxity
  7. 7Likened
  8. 8Like most of Mauritania and Malaysia, religiously
  9. 9Drenched
  10. 10See 47-Across
  11. 11Outdoor setting for Plato's Academy
  12. 12Cab driver?
  13. 13Did a number, say
  14. 15Decapod with three pairs of claws
  15. 21Sea foam
  16. 24Green land
  17. 25It borders Canada for 45 miles
  18. 26Certain miniature vehicle, informally
  19. 27Telekinetic intimidation tactic used in the "Star Wars" universe
  20. 28Offering to a teary person
  21. 31Anthony ___, author of 2021's "Cloud Cuckoo Land"
  22. 33Charles ___, founder of Cablevision and HBO
  23. 35Beverage that Ray Charles once touted as "The right one, baby"
  24. 38Medium for some ephemeral art
  25. 40Precious, in Italy
  26. 43Lama, e.g.
  27. 46Toothache medication
  28. 48Shady shelter
  29. 51Sky shade
  30. 52Yogurt-braised Indian entree
  31. 53Booth in Times Sq.
  32. 56Dutch soccer club that shares its name with a cleaning brand
  33. 5752-Down go-with
  34. 58Causes of some laundry mishaps
  35. 60Superlative ending
  36. 62Peat source

The answer to “Toothache medication” in the New York Times crossword is ORAJEL — a 6-letter word. It most recently appeared in the New York Times crossword on November 22, 2025, a Saturday puzzle, at 46-Down. Below you'll find why that fill fits, every other answer we've recorded for this clue, and links into the puzzle it came from.

“Toothache medication” answer

ORAJEL (6 letters)

Reveal the solution one letter at a time with the tiles above if you'd rather nudge yourself toward it than see the whole word at once. Just want it outright? The answer is ORAJEL.

Why the answer is ORAJEL

ORAJEL is the 6-letter solution that fits "Toothache medication" in the NYT Crossword crossword on November 22, 2025 (46-Down). Use the letter tiles above if you'd rather reveal it one letter at a time.

When else has “Toothache medication” appeared?

New York Times reuses clues across dates, sometimes with a different answer depending on the grid. Here's where this exact clue has shown up, and what the answer was each time — handy when you're checking whether today's fill is the only one.

November 22, 2025 (most recent) → ORAJEL. We haven't indexed another appearance of this exact clue yet.

Frequently asked questions

What is the answer to “Toothache medication”?

The answer is ORAJEL, a 6-letter word. It most recently appeared in the New York Times crossword on November 22, 2025.

How many letters is the answer to “Toothache medication”?

6 letters: ORAJEL.

When did this clue appear?

Most recently in the New York Times crossword on November 22, 2025 (a Saturday puzzle), at 46-Down.

Can “Toothache medication” have a different answer?

Yes — New York Times sometimes reuses a clue with a different solution to fit the grid. The answers we've recorded for each date it appeared are listed above when available.

Where can I find the rest of this day's NYT Crossword answers?

The full grid for November 22, 2025 is on the NYT Crossword answers page, with every clue and answer from that puzzle.

New York Times Crossword is published by The New York Times; WordHint is an independent site and is not affiliated with or endorsed by the publisher.

Crossword Clues

Looking up a clue? Jump into today's answers and clue help from top puzzles.