Target of a 1950s vaccine

The answer to “Target of a 1950s vaccine” in the USA Today crossword is POLIO — a 5-letter word. It most recently appeared in the USA Today crossword on July 6, 2026, a Monday puzzle, at 33-Down. Below you'll find why that fill fits, every other answer we've recorded for this clue, and links into the puzzle it came from.

“Target of a 1950s vaccine” answer

POLIO (5 letters)

Reveal the solution one letter at a time with the tiles above if you'd rather nudge yourself toward it than see the whole word at once. Just want it outright? The answer is POLIO.

Why the answer is POLIO

This disease was a major concern before vaccines made a difference in the 1950s! 💉

When else has “Target of a 1950s vaccine” appeared?

USA Today reuses clues across dates, sometimes with a different answer depending on the grid. Here's where this exact clue has shown up, and what the answer was each time — handy when you're checking whether today's fill is the only one.

July 6, 2026 (most recent) → POLIO. We haven't indexed another appearance of this exact clue yet.

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