the best medicine 4 Little Words

“the best medicine” answer

The 4 Little Words answer for “the best medicine” (Monday, September 21, 2026, Puzzle 2) is:

LAUGHTER·8 letters

You can also reveal it one tile at a time above if you'd rather keep some of the challenge.

When else has “the best medicine” appeared?

• September 21, 2026 (most recent) → LAUGHTER

Why the answer is LAUGHTER

LAUGHTER fits the clue “the best medicine” on Puzzle 2 for Monday, September 21, 2026. At 8 letters, it's one of the words you assemble from that puzzle's bank of ten tiles — and locking it in early clears tiles for the other three clues.

How to build LAUGHTER from the tiles

In 4 Little Words you don't type the answer — you assemble it from the puzzle's bank of ten tiles, each two to four letters long, and every tile is used exactly once across the four answers. Puzzle 2's tiles for September 21, 2026 are:

BLUF · FING · LA · UGHT · ER · BA · TTS · FOR · EC · ASTS

LAUGHTER is built by combining the tiles LA · UGHT · ER in order — 3 of the ten.

What this unlocks

Because the ten tiles cover the four answers exactly, with none left over, placing LAUGHTER removes 3 tiles from play and makes the rest of Puzzle 2 measurably easier. If this was your third answer, the tiles still sitting on the board are the fourth word — you can often assemble it without working out the clue at all.

More clues from this puzzle

Stuck on another clue? Here are the rest of Puzzle 2's clues for September 21, 2026 — tap any for its answer and tile breakdown:

• boldly misleading — 8 letters
• sections of insulation, say — 5 letters
• meteorologist's output — 9 letters

All of the day's answers

Want every puzzle in one place? All ten sets of clues and answers for September 21, 2026 are on the September 21, 2026 answers page, and today's live puzzles are always one tap away on the main 4 Little Words answers page.

About 4 Little Words

4 Little Words is a daily clue-and-tile puzzle from Blue Ox Family Games, the studio behind 7 Little Words. Each board gives four clues and ten letter tiles; you spell every answer by combining tiles, using each tile exactly once, so a finished puzzle leaves nothing behind. Ten puzzles publish every day — edited by Joe Jordan — and reset at midnight Eastern Time. This one ran on a Monday.